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Book the jakarta method
Book the jakarta method













book the jakarta method

If you are an author contributing to an RSC publication, you do not need to request permission Please go to the Copyright Clearance Center request page. To request permission to reproduce material from this article in a commercial publication,

book the jakarta method

Provided that the correct acknowledgement is given and it is not used for commercial purposes. This article in other publications, without requesting further permission from the RSC, Guo,Ĭreative Commons Attribution-NonCommercial 3.0 Unported Licence. Based on the results given by control experiments, three reaction models are proposed to illustrate the stereoselective-control outcomes.Ĭhiral Aldehyde Catalysis Enables Direct Asymmetric α−Substitution Reaction of N-Unprotected Amino Acids with Halohydrocarbons The asymmetric α−arylation reaction can be applied in the formal synthesis of the clinical candidate compound (+)-AG-041R. By promoting a simple chiral BINOL-aldehyde catalyst or combining catalysts of a chiral aldehyde and Lewis acid ZnCl2, the asymmetric α−arylation, α−allylation, and α−benzylation of amino acid esters with the corresponding halohydrocarbons proceed smoothly, producing α,α−disubstituted α−amino acids in moderate-to-high yields and good-to-excellent enantioselectivities. Herein, we report on three highly efficient aldehyde-catalyzed direct α−hydrocarbylations of N-unprotected amino acid esters with aryl-, allyl-, and benzyl halides.

book the jakarta method

However, all the reported methodologies depend on N-unprotected amino acids as starting materials. The direct catalytic α−hydrocarbylation of readily available amino acids with halohydrocarbons is one of the most straightforward methods leading to α,α−disubstituted non-proteinogenic α−amino acid compounds.















Book the jakarta method